Pulmonary Outcomes Associated with Long-Term Azithromycin Therapy in Cystic Fibrosis
نویسندگان
چکیده
منابع مشابه
Long term azithromycin therapy in patients with cystic fibrosis.
Inflammation is a central contributor to the pathogenesis of cystic fibrosis (CF) pulmonary disease; so limiting the excessive production of inflammatory mediators represents a major therapeutic strategy for slowing the decline in lung function and improving survival. The macrolide antibiotic azithromycin (AZM) has anti-inflammatory properties and immunomodulatory effects that may be beneficial...
متن کاملCYSTIC FIBROSIS Long term effects of azithromycin in patients with cystic fibrosis: a double blind, placebo controlled trial
Background: Macrolides display immunomodulatory effects that may be beneficial in chronic inflammatory pulmonary diseases. The aim of the study was to document whether long term use of azithromycin may be associated with respiratory benefits in young patients with cystic fibrosis. Methods: A multicentre, randomised, double blind, placebo controlled trial was conducted from October 2001 to June ...
متن کاملAzithromycin in cystic fibrosis.
We have read with interest the article by SOUTHERN and BARKER [1]. The authors critically reviewed the evidence from the randomised, controlled trials of the role of azithromycin in the management of cystic fibrosis (CF). In the three randomised, controlled studies described, the effects of up to 6 months of therapy with azithromycin in CF have been reported [2–4]. However, the controlled setti...
متن کاملLong-Term Pulmonal Therapy of Cystic Fibrosis-Patients with Amitriptyline.
BACKGROUND/AIMS Several recent clinical studies revealed an accumulation of ceramide in bronchial epithelial cells of patients with cystic fibrosis (CF). Degradation of ceramide concentrations in lungs of CF patients employing the functional acid sphingomyelinase inhibitor amitriptyline revealed a benefit in lung function, weight and exacerbation rates. METHODS To test for a beneficial effect...
متن کاملLong term effects of azithromycin in patients with cystic fibrosis: A double blind, placebo controlled trial.
BACKGROUND Macrolides display immunomodulatory effects that may be beneficial in chronic inflammatory pulmonary diseases. The aim of the study was to document whether long term use of azithromycin may be associated with respiratory benefits in young patients with cystic fibrosis. METHODS A multicentre, randomised, double blind, placebo controlled trial was conducted from October 2001 to June ...
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ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2020
ISSN: 1073-449X,1535-4970
DOI: 10.1164/rccm.201906-1206oc